N-(叔丁氧羰基)-2-氨基乙腈合成路线 （共 11 条）
反应条件
triethylamine in dichloromethane T=60°C; Sealed tube;
参考文献
Chen, Pinhong; Horton, Lori B.; Mikulski, Rose L.; Deng, Lisheng; Sundriyal, Sandeep; Palzkill, Timothy; Song, Yongcheng
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 19 p. 6229 - 6232
反应条件
pyridine; trifluoroacetic anhydride in tetrahydrofuran T=-10 - 0°C; 2 h;
参考文献
Sureshbabu, Vommina V.; Naik, Shankar A.; Nagendra
Synthetic Communications, 2009 , vol. 39, # 3 p. 395 - 406
反应条件
sodium hydroxide in 1,4-dioxane; water 24 h; Ambient temperature;
参考文献
Matt, Thomas; Seebach, Dieter
Helvetica Chimica Acta, 1998 , vol. 81, # 10 p. 1845 - 1895
反应条件
1.1: KH / tetrahydrofuran / 1 h / 0 °C 1.2: 100 percent / tetrahydrofuran / 14 h / 20 °C 2.1: 70 percent / TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 26 p. 9152 - 9156
反应条件
1: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 2: 85 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., View Scheme
参考文献
Synthesis, , # 3 p. 259 - 261
反应条件
1: With triethylamine in methanol 2: With trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane Further stages;
参考文献
Schotes, Christoph; Ostrovskyi, Dmytro; Senger, Johanna; Schmidtkunz, Karin; Jung, Manfred; Breit, Bernhard
Chemistry - A European Journal, 2014 , vol. 20, # 8 p. 2164 - 2168
反应条件
hydrogen sulfide; diethylamine in toluene T=-10 - 20°C;
参考文献
Abbott GmbH and Co., KG
Patent: US6740647 B1, 2004 ;
Location in patent: Page column 37 ;
US 6740647 B1
反应条件
1: 76 percent / NH3; H2S / methanol / 20 °C 2: 74 percent / CaCO3 / ethanol / 6 h / 20 °C View Scheme
参考文献
Bailly, Christian; Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Tetrahedron, 1988 , vol. 44, # 18 p. 5833 - 5844
反应条件
methanesulfonic acid in tetrahydrofuran T=20°C; 18 h;
参考文献
Guay, Daniel; Beaulieu, Christian; Jagadeeswar Reddy; Zamboni, Robert; Methot, Nathalie; Rubin, Joel; Ethier, Diane; David Percival
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 18 p. 5392 - 5396
反应条件
ammonia; hydrogen; nickel in ethanol P=2585.7 Torr; 14 h; Ambient temperature;
参考文献
Ravikumar
Synthetic Communications, 1994 , vol. 24, # 12 p. 1767 - 1772
