2-氰基-3,5-二氯吡啶合成路线 (共 7 条)
反应条件
N,N-dimethylcarbamoyl chloride in dichloromethane T=20°C; 48 h;
参考文献
Goldmann, Siegfried; Stoltefuss, Jurgen; Niewohner, Ulrich; Schlemmer, Karl-Heinz; Keldenich, Jorg; Paessens, Arnold; Graef, Erwin; Weber, Olaf; Deres, Karl
Patent: US2003/232842 A1, 2003 ;
Location in patent: Page 8 ;
反应条件
copper (I) cyanide; tetra-phenylphosphonium bromide; potassium iodide in diethylene glycol dimethyl ether 113 h; Heating / reflux;
参考文献
Goldmann, Siegfried; Stoltefuss, Jurgen; Niewohner, Ulrich; Schlemmer, Karl-Heinz; Keldenich, Jorg; Paessens, Arnold; Graef, Erwin; Weber, Olaf; Deres, Karl
Patent: US2003/232842 A1, 2003 ;
Location in patent: Page 8 ;
反应条件
triethylamine in acetonitrile
参考文献
Meyer; Michael D.; Altenbach; Robert J.; Basha; Fatima Z.; Carroll; William A.; Drizin; Irene; Kerwin, Jr.; James F.; Wendt; Michael D.; Haight; Anthony R.; Zhang; Weijiang
Patent: US6046207 A1, 2000 ;
Title/Abstract Full Text Show Details
Abbott Laboratories
Patent: US5891882 A1, 1999 ;
参考文献
US5716971 A1, ;
US 5716971 A
反应条件
sulfuric acid; water T=115°C;
参考文献
ARDEA BIOSCIENCES INC.
Patent: WO2009/89263 A2, 2009 ;
Location in patent: Page/Page column 117 ;
反应条件
sodium hydride in tetrahydrofuran T=0 - 190°C; 5 h; microwave;
参考文献
The Procter and Gamble Company
Patent: US2007/299086 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070299086 A1
反应条件
polyethylene glycol 8000; potassium fluoride in dimethyl sulfoxide T=160°C; 0.5 h;
参考文献
Goldmann, Siegfried; Stoltefuss, Jurgen; Niewohner, Ulrich; Schlemmer, Karl-Heinz; Keldenich, Jorg; Paessens, Arnold; Graef, Erwin; Weber, Olaf; Deres, Karl
Patent: US2003/232842 A1, 2003 ;
Location in patent: Page 8 ;