1: (6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide With trimethylsilyl trifluoromethanesulfonate; triethylamine in dichloromethane T=-2 - 18°C; 14 h; 2: ethyl-isocyanate in dichloromethane T=18°C; 48 h; 3: With tetrabutyl ammonium fluoride in tetrahydrofuran; dichloromethane T=-2°C; 4 h;

in toluene Heating;

1: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C 2: NaHMDS / tetrahydrofuran / -40 - 20 °C 3: propan-2-ol / 18 h / 50 °C 4: aqueous hydrochloric acid / H2O / 1 h / 80 °C View Scheme

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