(4S)-2,2-二甲基-1,3-二噁烷-4-甲醇合成路线 （共 11 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Mori, Kenji; Uematsu, Tamon; Watanabe, Hidenori; Yanagi, Kazunori; Minobe, Masao
Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3875 - 3878
反应条件
1: 77 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature
2: BF3*Et2O / diethyl ether / 3 h / Ambient temperature
View Scheme
参考文献
Meyers; Lawson; Walker; Linderman
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5111 - 5123
反应条件
1: 28 percent / 1.) BF3.Et2O; 2.) NaHCO3 powder / diethyl ether / 1.) rt, overnight; 2.) 2 h
2: 1.) LAH; 2.) 15percent aq NaOH / 1.) ether, 1 h, rt; 2.) water, ether, 3 h, rt
View Scheme
参考文献
Mori, Kenji; Uematsu, Tamon; Yanagi, Kazunori; Minobe, Masao
Tetrahedron, 1985 , vol. 41, # 13 p. 2751 - 2758
反应条件
1: 94 percent / NaOEt, EtOH / 0.5 h / Ambient temperature
2: 28 percent / 1.) BF3.Et2O; 2.) NaHCO3 powder / diethyl ether / 1.) rt, overnight; 2.) 2 h
3: 1.) LAH; 2.) 15percent aq NaOH / 1.) ether, 1 h, rt; 2.) water, ether, 3 h, rt
View Scheme
参考文献
Mori, Kenji; Uematsu, Tamon; Yanagi, Kazunori; Minobe, Masao
Tetrahedron, 1985 , vol. 41, # 13 p. 2751 - 2758
反应条件
boron trifluoride diethyl etherate in diethyl ether
3 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Meyers; Lawson; Walker; Linderman
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5111 - 5123
反应条件
toluene-4-sulfonic acid in benzene
48 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Meyers; Lawson; Walker; Linderman
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5111 - 5123
反应条件
1: reduction
2: 10 percent / BF3*Et2O / CHCl3 / 3 h / 25 °C
View Scheme
参考文献
Meyers, A.I.; Lawson, Jon P.
Tetrahedron Letters, 1982 , vol. 23, # 47 p. 4883 - 4886
反应条件
1: LiAlH4 / tetrahydrofuran
2: 10 percent / BF3*Et2O / CHCl3 / 3 h / 25 °C
View Scheme
参考文献
Meyers, A.I.; Lawson, Jon P.
Tetrahedron Letters, 1982 , vol. 23, # 47 p. 4883 - 4886
反应条件
1: 83 percent / K2CO3 / methanol / 18 h / 23 °C
2: 10 percent / BF3*Et2O / CHCl3 / 3 h / 25 °C
View Scheme
参考文献
Meyers, A.I.; Lawson, Jon P.
Tetrahedron Letters, 1982 , vol. 23, # 47 p. 4883 - 4886
反应条件
boron trifluoride diethyl etherate in chloroform
T=25°C; 3 h;
参考文献
Meyers, A.I.; Lawson, Jon P.
Tetrahedron Letters, 1982 , vol. 23, # 47 p. 4883 - 4886
