1-Boc-3-羟基哌啶合成路线 （共 34 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
Audouze, Karine; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; Peters, Dan; Liljefors, Tommy; Balle, Thomas
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3159 - 3171
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
LG LIFE SCIENCES, LTD.
Patent: WO2009/82134 A2, 2009 ;
Location in patent: Page/Page column 36-37 ;
WO 2009/082134 A2
反应条件
in dichloromethane T=20°C; 15 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 93 ;
EP 1403255 A1
反应条件
sodium carbonate in 1,4-dioxane; water
参考文献
US2002/156081 A1, ;
US 20020156081 A1
反应条件
triethylamine in ethanol; ethyl acetate
参考文献
US2004/19058 A1, ;
US 20040019058 A1
反应条件
sodium hydroxide in 1,4-dioxane; hexane; ethyl acetate
参考文献
US2001/44454 A1, ;
US 20010044454 A1
反应条件
in water; tert-butyl alcohol
反应条件
sodium hydride in tetrahydrofuran T=20°C; Methylation; 6 h;
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 89 percent / NaH / tetrahydrofuran / 6 h / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 2.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 3.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 22 h; Inert atmosphere;
参考文献
COATS, STEVEN J.; BIAN, HAIYAN; CONNOLLY, PETER J.; BIGNAN, GILLES; CAI, CHAOZHONG; DAX, SCOTT L.; DECORTE, BART L.; LIN, SHU-CHEN; LIU, LI; MACIELAG, MARK J.; PITIS, PHILIP M.; ZHANG, YUE-MEI; ZHU, BIN; HE, WEI
Patent: US2011/105520 A1, 2011 ;
Location in patent: Page/Page column 36 ;
