6-氯-3-苯基-2-喹啉醇合成路线 （共 9 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; intramolecular Aldol-type condensation;
参考文献
Park, Kwanghee Koh; Jung, Jin Young
Heterocycles, 2005 , vol. 65, # 9 p. 2095 - 2105
反应条件
1: acetophenone; 1-(4-chlorophenyl)hydrazine With phosphoric acid in water
T=100 - 110°C; 0.666667 h;
2: β-NO2 styrene With water
T=80 - 85°C; 0.5 h; Further stages;
参考文献
Aksenov, Alexander V.; Smirnov, Alexander N.; Aksenov, Nicolai A.; Aksenova, Inna V.; Frolova, Liliya V.; Kornienko, Alexander; Magedov, Igor V.; Rubin, Michael
Chemical Communications, 2013 , vol. 49, # 81 p. 9305 - 9307
反应条件
copper(l) iodide; caesium carbonate; N-methyl-2-(methylamino)ethylamine in toluene
T=110°C; 24 h; Inert atmosphereSealed tube;
参考文献
Fu, Liangbing; Huang, Xiaoli; Wang, Deping; Zhao, Pinghua; Ding, Ke
Synthesis, 2011 , # 10 art. no. H19211SS, p. 1547 - 1554
反应条件
aluminium trichloride in chlorobenzene
Heating;
参考文献
Natarajan, M.; Manimaran, T.; Ramakrishnan, V. T.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 6 p. 529 - 534
反应条件
palladium diacetate; triethylamine; 1,2-bis-(diphenylphosphino)ethane in tetrahydrofuran
T=60 - 160°C; 0.666667 h; Inert atmosphereMicrowave irradiation;
参考文献
Chen, Jia-Rong; Liao, Jie; Xiao, Wen-Jing
Canadian Journal of Chemistry, 2010 , vol. 88, # 4 p. 331 - 337
反应条件
1: iron; acetic acid / aq. ethanol / Heating
2: pyridine / benzene / 20 °C
3: 97 percent / K2CO3 / dimethylformamide / 60 °C
View Scheme
参考文献
Park, Kwanghee Koh; Jung, Jin Young
Heterocycles, 2005 , vol. 65, # 9 p. 2095 - 2105
反应条件
1: pyridine / benzene / 20 °C
2: 97 percent / K2CO3 / dimethylformamide / 60 °C
View Scheme
参考文献
Park, Kwanghee Koh; Jung, Jin Young
Heterocycles, 2005 , vol. 65, # 9 p. 2095 - 2105
反应条件
1: 70 percent / conc. sulphuric acid / Heating
2: 60 percent / anhydr. AlCl3 / chlorobenzene / Heating
View Scheme
参考文献
Natarajan, M.; Manimaran, T.; Ramakrishnan, V. T.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 6 p. 529 - 534
反应条件
trichlorophosphate
2 h; Heating;
参考文献
Blackburn, Thomas P.; Cox, Barry; Guildford, Allen J.; Count, David J. Le; Middlemiss, Derek N.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2252 - 2259
