2,4-二氯-6-三氟甲基喹啉合成路线 （共 7 条）
反应条件
trichlorophosphate in 1,4-dioxane
T=120°C; 0.25 h; microwave irradiation;
参考文献
Glasnov, Toma N.; Stadlbauer, Wolfgang; Kappe, C. Oliver
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3864 - 3870
反应条件
1: aq. K2CO3 / methanol / 24 h / 50 °C
2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C
3: TBAF / tetrahydrofuran / 0 - 20 °C
4: 25 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: ICl / dimethylformamide / 0.5 h / 20 °C
2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C
3: TBAF / tetrahydrofuran / 0 - 20 °C
4: 25 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C
2: TBAF / tetrahydrofuran / 0 - 20 °C
3: 25 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
in acetonitrile
T=150°C; 12 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: 65 percent / phosphorus pentoxide; methanesulfonic acid / 0.33 h / 120 °C / microwave irradiation
2: 81 percent / phosphorus oxychloride / dioxane / 0.25 h / 120 °C / microwave irradiation
View Scheme
参考文献
Glasnov, Toma N.; Stadlbauer, Wolfgang; Kappe, C. Oliver
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3864 - 3870
反应条件
1: TBAF / tetrahydrofuran / 0 - 20 °C
2: 25 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
