water; potassium hydroxide T=60°C; Large scale;

1: potassium carbonate / acetonitrile 2: trifluoroacetic acid; triethylsilane / dichloromethane / 0 - 20 °C 3: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C View Scheme

1: triethylsilane; trifluoroacetic acid / dichloromethane; toluene / 6 h / |Reflux; |Large scale 2: potassium hydroxide; water / 60 °C / |Large scale View Scheme

1: trifluoroacetic acid / dichloromethane; toluene / 2 h / 5 °C / |Large scale 2: triethylsilane; trifluoroacetic acid / dichloromethane; toluene / 6 h / |Reflux; |Large scale 3: potassium hydroxide; water / 60 °C / |Large scale View Scheme