1: With ammonia; water; zinc in dichloromethane 2 h; Reflux; 2: With hydrogenchloride in dichloromethane; water pH=7;

trichlorophosphate 2 h; Heating / reflux;

1: hydrogenchloride; water / acetone / 2 h / 20 °C 2: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 3: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: toluene-4-sulfonic acid / toluene / 100 °C 3: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C 4: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 5: hydrogenchloride; water / acetone / 2 h / 20 °C 6: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 7: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme

1: toluene-4-sulfonic acid / toluene / 100 °C 2: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C 3: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 4: hydrogenchloride; water / acetone / 2 h / 20 °C 5: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 6: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 2: hydrogenchloride; water / acetone / 2 h / 20 °C 3: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 4: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme

1: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C 2: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 3: hydrogenchloride; water / acetone / 2 h / 20 °C 4: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 5: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme

1.1: N,N-diethylaniline; trichlorophosphate / 6 h / Reflux 2.1: zinc; water; ammonia / dichloromethane / 2 h / Reflux 2.2: pH 7 View Scheme

1.1: 1 h / 200 °C 2.1: N,N-diethylaniline; trichlorophosphate / 6 h / Reflux 3.1: zinc; water; ammonia / dichloromethane / 2 h / Reflux 3.2: pH 7 View Scheme

1: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 2: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme