1: Diethyl {[4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetrahydrofuran-3-Yloxy)-Quinazolin-6-Ylcarbamoyl]-Methyl}-Phosphonate With lithium chloride in ethanol T=-5°C; 2: dimethylaminoacetaldehyde-hydrogen sulphite adduct With potassium hydroxide in ethanol; water 1 h;

1: N,N-Dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride in water T=30 - 35°C; 8.3 h; Large scale; 2: diethyl ((4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazoline-6-ylcarbamoyl)methyl)phosphonate With lithium chloride; potassium hydroxide in water T=-7 - -5°C; 2 h; Large scale;

1: N,N-Dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride in water T=20 - 30°C; Inert atmosphere; 2: Diethyl {[4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetrahydrofuran-3-Yloxy)-Quinazolin-6-Ylcarbamoyl]-Methyl}-Phosphonate With lithium chloride; potassium hydroxide in tetrahydrofuran T=-15 - 20°C; 2.5 h; Inert atmosphere; Product distribution / selectivity;