(2-甲基-1-萘基)乙酸合成路线 （共 8 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in (naphth-1-yl)acetic acid; ethyl acetate; acetonitrile
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6054470 A1, 2000 ;
US 6054470 A
反应条件
sulfuric acid in water
参考文献
Knobelsdorf, James; Hays, Sheryl; Stankovic, Charles J.; Para, Kimberly S.; Connolly, Michael K.; Galatsis, Paul; Harter, William; Shahripour, Aurash B.; Plummer, Mark Stephen; Lunney, Beth; Janssen, Bernd; Fell, Jay Bradford
Patent: US2003/96826 A1, 2003 ;
反应条件
1: 2-methyl-butan-2-ol / Heating
2: Pd-C / 180 °C
3: (i) <Et3O>BF4, CH2Cl2, (ii) aq. KOH, MeOH
4: SOCl2
View Scheme
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
反应条件
1: Pd-C / 180 °C
2: (i) <Et3O>BF4, CH2Cl2, (ii) aq. KOH, MeOH
3: SOCl2
View Scheme
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
反应条件
1: (i) <Et3O>BF4, CH2Cl2, (ii) aq. KOH, MeOH
2: SOCl2
View Scheme
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
参考文献
Lawesson
Acta Chemica Scandinavica (1947-1973), 1958 , vol. 12, p. 1,7
参考文献
Canceill,J. et al.
Bulletin de la Societe Chimique de France, 1974 , p. 2833 - 2838
