1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-100°C; 0.75 h; 2: With 1,2,2-trifluoro-trichloroethane in tetrahydrofuran; hexane T=-75°C; 0.75 h;

trichlorophosphate T=130°C;

ammonium hydroxide T=160°C;

1.1: BuLi / diethyl ether; hexane / 0.75 h / -75 °C 1.2: 89 percent / diethyl ether; hexane 2.1: H2O / 60 h / 50 °C 3.1: 3.37 g / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C View Scheme