4-甲氧基-7-甲基-7H-吡咯并[2,3-d]嘧啶-2-胺合成路线 （共 6 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C;
参考文献
Hornillo-Araujo, Ana R.; Burrell, Adam J.M.; Aiertza, Miren K.; Shibata, Takayuki; Hammond, David M.; Edmont, Dolores; Adams, Harry; Margison, Geoffrey P.; Williams, David M.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1723 - 1729
反应条件
in methanol
24 h; Heating;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: 77 percent / benzyltriethylammonium chloride, 50percent aq. NaOH / CH2Cl2; 1,2-dimethoxy-ethane / 0.83 h
2: 75 percent / methanol / 24 h / Heating
View Scheme
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
反应条件
1: 78 percent / 1 N NaOH / methanol / 3 h / Heating
2: 76 percent / benzyltriethylammonium chloride, N,N-dimethylaniline, POCl3 / acetonitrile / 1 h / Heating
3: 82 percent / methanol / 24 h / Heating
4: 68 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2; 1,2-dimethoxy-ethane / 0.5 h
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
1: 76 percent / benzyltriethylammonium chloride, N,N-dimethylaniline, POCl3 / acetonitrile / 1 h / Heating
2: 82 percent / methanol / 24 h / Heating
3: 68 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2; 1,2-dimethoxy-ethane / 0.5 h
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
4-MeC6H4SNa in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene
4 h; Heating;
参考文献
Seela; Bussmann; Gotze; Rosemeyer
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 981 - 985
