4-甲氧基-1H-吡咯并[2,3-d]嘧啶-2-胺合成路线 （共 10 条）
反应条件
1: 50percent aq. NaOH / Bu4NHSO4 / CH2Cl2 / Ambient temperature; liquid-liquid phase-transfer glycosylation 2: 2M KOH / 80 °C View Scheme
参考文献
Winkeler, Heinz-Dieter; Seela, Frank
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3119 - 3122
反应条件
1: 1) KOH, tris<2-(2-methoxyethoxy)ethyl>amine / 1) MeCN, 10 min, 2) r.t., 20 h 2: 68 percent / 90percent aq. CF3COOH / 1 h / Ambient temperature View Scheme
参考文献
Seela; Soulimane; Mersmann; Jurgens
Helvetica Chimica Acta, 1990 , vol. 73, # 7 p. 1879 - 1887
反应条件
potassium hydroxide; tri[2-(2-methoxyethoxy)ethyl]amine 1) MeCN, 10 min, 2) r.t., 20 h; Yield given. Multistep reaction;
参考文献
Seela; Soulimane; Mersmann; Jurgens
Helvetica Chimica Acta, 1990 , vol. 73, # 7 p. 1879 - 1887
反应条件
in methanol
24 h; Heating;
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
1: 49 percent / POCl3 / 2 h / Heating
2: 70 percent / methanol / 24 h / Heating
View Scheme
参考文献
Shih, Chuan; Gossett, L. S.
Heterocycles, 1993 , vol. 35, # 2 p. 825 - 841
反应条件
1: 78 percent / 1 N NaOH / methanol / 3 h / Heating
2: 76 percent / benzyltriethylammonium chloride, N,N-dimethylaniline, POCl3 / acetonitrile / 1 h / Heating
3: 82 percent / methanol / 24 h / Heating
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C;
参考文献
Hornillo-Araujo, Ana R.; Burrell, Adam J.M.; Aiertza, Miren K.; Shibata, Takayuki; Hammond, David M.; Edmont, Dolores; Adams, Harry; Margison, Geoffrey P.; Williams, David M.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1723 - 1729
反应条件
1: 1) 50percent NaOH, tetrabutylammonium hydrogensulfate / 1) benzene, 2) 1 min
2: 68 percent / conc. NH3 / methanol / 3 h / Ambient temperature
3: 69 percent / sodium 4-methylthiophenolate, HMPT / toluene / 3 h / Heating
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane
Ambient temperatureliquid-liquid phase-transfer glycosylation; Yield given;
参考文献
Seela, Frank; Westermann, Bernhard; Bindig, Uwe
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 697 - 702
反应条件
sodium hydroxide; ammonia; Aliquatreg; 336
1.) C6H6, dimethoxyethane, 2.) CH3OH, 24 h, room temp.; Yield given. Multistep reaction;
参考文献
Wilson; Hager; El-Kattan; Liotta
Synthesis, 1995 , # 12 p. 1465 - 1479
