2-氨基-4-氯吡咯并[2,3-D]嘧啶合成路线 （共 36 条）
反应条件
1: 84 percent / pyridine / 5 h / 20 °C 2: 85 percent / N-iodosuccinimide / CH2Cl2 / 5 h / 40 °C View Scheme
参考文献
Shih, Chuan; Gossett, L. S.
Heterocycles, 1993 , vol. 35, # 2 p. 825 - 841
反应条件
pyridine T=20°C; 5 h;
参考文献
Seela, Frank; Peng, Xiaohua
Synthesis, 2004 , # 8 p. 1203 - 1210
反应条件
1: With pyridine; tert.-butylnitrite; hydrogen fluoride T=-60 - -40°C; Teflon bottle; 2: With potassium carbonate in chloroform; water Cooling;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; CHAND, Pooran; KOTIAN, Pravin, L.; KUMAR, V., Satish
Patent: WO2010/14930 A2, 2010 ;
Location in patent: Page/Page column 57-58 ;
WO 2010/014930 A2
反应条件
1: 84 percent / pyridine / 5 h / 20 °C
2: 81 percent / N-chlorosuccinimide / CH2Cl2 / 5 h / 40 °C
View Scheme
参考文献
Seela, Frank; Peng, Xiaohua
Synthesis, 2004 , # 8 p. 1203 - 1210
反应条件
1: 84 percent / pyridine / 5 h / 20 °C
2: 80 percent / N-bromosuccinimide / CH2Cl2 / 5 h / 40 °C
View Scheme
参考文献
Seela, Frank; Peng, Xiaohua
Synthesis, 2004 , # 8 p. 1203 - 1210
反应条件
in methanol
24 h; Heating;
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
1: 77 percent / benzyltriethylammonium chloride, 50percent aq. NaOH / CH2Cl2; 1,2-dimethoxy-ethane / 0.83 h
2: 75 percent / methanol / 24 h / Heating
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
1: 82 percent / methanol / 24 h / Heating
2: 1) 50percent NaOH, tetrabutylammonium hydrogensulfate / 1) benzene, 2) 1 min
3: 68 percent / conc. NH3 / methanol / 3 h / Ambient temperature
4: 69 percent / sodium 4-methylthiophenolate, HMPT / toluene / 3 h / Heating
View Scheme
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
反应条件
1.1: sodium hydride / acetonitrile / 1 h / 20 °C
1.2: 78 percent / acetonitrile / 3 h / 20 °C
2.1: 93 percent / Dowex 550A / 2 h / Heating
View Scheme
参考文献
Ramasamy; Imamura; Robins; Revankar
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5107 - 5110
反应条件
pyridine
T=0°C; 0.333333 h;
参考文献
Kawate, Tomohiko; Wang, Bing H.; Allerson, Charles R.; Wolfe, Jia Liu
Synthesis, 2006 , # 19 p. 3280 - 3290
