1-(4-氟苄基)-2-氯苯并咪唑合成路线 （共 16 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=60°C; 18 h;
参考文献
Martin, Rainer E.; Green, Luke G.; Guba, Wolfgang; Kratochwil, Nicole; Christ, Andreas
Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6291 - 6294
反应条件
sodium hydride 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
trichlorophosphate 5.5 h; Heating;
参考文献
De Parrodi, Cecilia Anaya; Quintero-Cortes, Leticia; Sandoval-Ramirez, Jesus
Synthetic Communications, 1996 , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: p-FC6H4CH2X in N,N-dimethyl-formamide Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 16 p. 2133 - 2136
反应条件
1: 72 percent / phosphoryl chloride / 4 h / Heating 2: 1.) NaH / 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5 h View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 1.) NaH / 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5.5 h 2: 84 percent / phosphoryl chloride / 5.5 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
T=180°C; 1 h; microwave irradiation;
参考文献
Martin, Rainer E.; Green, Luke G.; Guba, Wolfgang; Kratochwil, Nicole; Christ, Andreas
Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6291 - 6294
反应条件
sodium hydroxide in water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4835161 A1, 1989 ;
反应条件
lutidine; cesium fluoride in various solvent(s) T=120°C; Substitution; 3 h; Product distribution; Further Variations:ReagentsSolventsTemperaturespH-values;
参考文献
Senanayake, Chris H.; Hong, Yaping; Xiang, Tingjian; Scott Wilkinson; Bakale, Roger P.; Jurgens, Alex R.; Pippert, Mark F.; Butler, Hal T.; Wald, Stephen A.
Tetrahedron Letters, 1999 , vol. 40, # 38 p. 6875 - 6879
反应条件
1: 56 percent / 5 h / 125 °C 2: 95 percent / aq. HBr / 1 h / Heating 3: 1.) NaH, KI / 1.) DMF, 70 deg C, 10 h, 2.) DMF, 70 deg C, 12 h View Scheme
参考文献
De Parrodi, Cecilia Anaya; Quintero-Cortes, Leticia; Sandoval-Ramirez, Jesus
Synthetic Communications, 1996 , vol. 26, # 17 p. 3323 - 3329
