(3-溴-4-氯苯基)甲胺合成路线 （共 2 条）
反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere
2.1: ammonium hydroxide / ethyl acetate / 0.5 h
3.1: dimethylsulfide borane complex / tetrahydrofuran / 192 h / 60 °C
3.2: 4 h / 50 °C / pH 2
3.3: pH 10
View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1.1: ammonium hydroxide / ethyl acetate / 0.5 h
2.1: dimethylsulfide borane complex / tetrahydrofuran / 192 h / 60 °C
2.2: 4 h / 50 °C / pH 2
2.3: pH 10
View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
