sodium azide T=45°C;

sodium azide T=45°C;

sodium azide T=45°C;

1: With triphenylphosphine in tetrahydrofuran T=0 - 4°C; 2: With diethylazodicarboxylate in tetrahydrofuran T=20°C; 24 h;

1: triethylamine / N,N-dimethyl-formamide / 72 h 2: triethylamine / 8 h View Scheme

1: subtilisin from Bacillus lichenifirmis; ammonium hydroxide / water; N,N-dimethyl-formamide / 3 h / 40 °C / pH 8 / |Resolution of racemate; |Enzymatic reaction 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 3: sodium hydroxide / ethanol; water / 2 h / 0 °C 4: hydrogenchloride / water; 1,4-dioxane / 1 h / 0 - 20 °C 5: triethylamine / N,N-dimethyl-formamide / 72 h 6: triethylamine / 8 h View Scheme

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 2: sodium hydroxide / ethanol; water / 2 h / 0 °C 3: hydrogenchloride / water; 1,4-dioxane / 1 h / 0 - 20 °C 4: triethylamine / N,N-dimethyl-formamide / 72 h 5: triethylamine / 8 h View Scheme

triethylamine 8 h;