3-碘-4-[(三氟乙酰基)氨基]苯甲酸甲酯合成路线 （共 4 条）
反应条件
in tetrahydrofuran
T=0°C; 0.166667 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2005/34941 A1, 2005 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With pyridine in dichloromethane
T=0 - 20°C;
2: With hydrogenchloride in dichloromethane; water
参考文献
Pfizer Inc
Patent: US2006/69087 A1, 2006 ;
Location in patent: Page/Page column 14 ;
US 20060069087 A1
反应条件
copper(l) iodide; N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=50°C;
参考文献
AstraZeneca AB
Patent: US2009/131468 A1, 2009 ;
Location in patent: Page/Page column 67 ;
US 20090131468 A1
反应条件
potassium carbonate; L-proline; copper(I) bromide in dimethyl sulfoxide
T=100°C; 3 h; Inert atmosphere;
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252
