4-氨基-2,6-二溴-3-硝基吡啶合成路线 （共 8 条）
反应条件
1: With sulfuric acid; nitric acid
T=0 - 20°C; 0.75 h;
2: With sulfuric acid
T=100°C; 0.75 h;
参考文献
ALTANA PHARMA AG
Patent: WO2005/26164 A1, 2005 ;
Location in patent: Page/Page column 44 ;
反应条件
sulfuric acid
T=47 - 56°C; 1.58333 h;
参考文献
Hay, Duncan A.; Adam, Fiona M.; Bish, Gerwyn; Calo, Frederick; Dixon, Rachel; Fray, M. Jonathan; Hitchin, James; Jones, Peter; Paradowski, Michael; Parsons, Gemma C.; Proctor, Katie J.W.; Pryde, David C.; Smith, Nicholas N.
Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5728 - 5732
反应条件
hydrogen bromide; acetic acid
T=90°C; 72 h; Heating in a teflon-lined bomb; Product distribution / selectivity;
参考文献
PFIZER LIMITED
Patent: US2007/197478 A1, 2007 ;
Location in patent: Page/Page column 70 ;
反应条件
1: urea hydrogen peroxide addition compound; trifluoroacetic anhydride / dichloromethane / 20.75 h / 5 - 20 °C / Inert atmosphere
2: sulfuric acid; nitric acid / 3.92 h / 79 - 85 °C
3: iron; acetic acid / 0.75 h
4: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
5: sulfuric acid / 1.58 h / 47 - 56 °C
View Scheme
参考文献
Hay, Duncan A.; Adam, Fiona M.; Bish, Gerwyn; Calo, Frederick; Dixon, Rachel; Fray, M. Jonathan; Hitchin, James; Jones, Peter; Paradowski, Michael; Parsons, Gemma C.; Proctor, Katie J.W.; Pryde, David C.; Smith, Nicholas N.
Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5728 - 5732
反应条件
1.1: nitric acid; sulfuric acid / 0.5 h / 0 °C
2.1: sulfuric acid / 0.33 h / 105 °C
2.2: 6 h / 4 °C
3.1: hydrogen bromide; acetic acid / 72 h / 90 °C
View Scheme
参考文献
IRM LLC; CORTEZ, Alex; LI, Yongkai; LIAO, Xuebin; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue
Patent: WO2011/57148 A1, 2011 ;
反应条件
1.1: sulfuric acid / 0.33 h / 105 °C
1.2: 6 h / 4 °C
2.1: hydrogen bromide; acetic acid / 72 h / 90 °C
View Scheme
参考文献
IRM LLC; CORTEZ, Alex; LI, Yongkai; LIAO, Xuebin; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue
Patent: WO2011/57148 A1, 2011 ;
反应条件
1: sulfuric acid; nitric acid / 3.92 h / 79 - 85 °C
2: iron; acetic acid / 0.75 h
3: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
4: sulfuric acid / 1.58 h / 47 - 56 °C
View Scheme
参考文献
Hay, Duncan A.; Adam, Fiona M.; Bish, Gerwyn; Calo, Frederick; Dixon, Rachel; Fray, M. Jonathan; Hitchin, James; Jones, Peter; Paradowski, Michael; Parsons, Gemma C.; Proctor, Katie J.W.; Pryde, David C.; Smith, Nicholas N.
Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5728 - 5732
反应条件
1: iron; acetic acid / 0.75 h
2: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C
3: sulfuric acid / 1.58 h / 47 - 56 °C
View Scheme
参考文献
Hay, Duncan A.; Adam, Fiona M.; Bish, Gerwyn; Calo, Frederick; Dixon, Rachel; Fray, M. Jonathan; Hitchin, James; Jones, Peter; Paradowski, Michael; Parsons, Gemma C.; Proctor, Katie J.W.; Pryde, David C.; Smith, Nicholas N.
Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5728 - 5732
