2-氨基-2-甲基丙酸叔丁酯盐酸盐合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther
Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182
反应条件
1: phosgene; 4-amino-2-(trifluoromethyl)benzonitrile in toluene; acetonitrile
T=70°C;
2: tert-butyl 2-amino-2-methylpropanoate hydrochloride With triethylamine in toluene; acetonitrile
T=20°C;
3: With hydrogenchloride; water in toluene; acetonitrile
T=70°C; 1 h;
参考文献
SANOFI-AVENTIS
Patent: US2011/178134 A1, 2011 ;
Location in patent: Page/Page column 37 ;
参考文献
Stamm, Simon; Linden, Anthony; Heimgartner, Heinz
Helvetica Chimica Acta, 2006 , vol. 89, # 1 p. 1 - 15
