3-溴-7-甲氧基-1-萘腈合成路线 （共 8 条）
反应条件
1: With bromine in acetic acid
T=45°C; Reflux;
2: With hydrogenchloride; SnCl4 in water; acetic acid
T=100°C;
参考文献
Hartmann, Rolf; Frotscher, Martin; Oberwinkler, Sandrine; Ziegler, Erika; Messinger, Josef; Thole, Heinrich-Hubert
Patent: US2010/204234 A1, 2010 ;
Location in patent: Page/Page column 14 ;
US 20100204234 A1
反应条件
hydrogenchloride; acetic acid; tin(ll) chloride in water
T=100°C; 6 h;
参考文献
Wyeth
Patent: US2005/54870 A1, 2005 ;
Location in patent: Page/Page column 3; 5; 7 ;
反应条件
1.1: ZnI2 / benzene / 20 °C
1.2: POCl3; pyridine / benzene / 6 h / Heating
2.1: p-cymene / Pd/C / Heating
3.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
4.1: Br2; acetic acid / 6 h / 100 °C
4.2: aq. HCl; SnCl2 / 1 h / 100 °C
5.1: 2.41 g / K2CO3 / acetone / Heating
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: p-cymene / Pd/C / Heating
2.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
3.1: Br2; acetic acid / 6 h / 100 °C
3.2: aq. HCl; SnCl2 / 1 h / 100 °C
4.1: 2.41 g / K2CO3 / acetone / Heating
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: Br2; acetic acid / 6 h / 100 °C
1.2: aq. HCl; SnCl2 / 1 h / 100 °C
2.1: 2.41 g / K2CO3 / acetone / Heating
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
potassium carbonate in acetone
Heating;
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=20°C;
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
pyridine hydrochloride
T=190°C; 2 h;
参考文献
Marchais-Oberwinkler, Sandrine; Krachten, Patricia; Frotscher, Martin; Ziegler, Erika; Neugebauer, Alexander; Bhoga, Umadevi; Bey, Emmanuel; Mueller-Vieira, Ursula; Messinger, Josef; Thole, Hubert; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4685 - 4698
