3-(BOC-氨基)环戊酮合成路线 （共 8 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate 18 h;
参考文献
Thompson, Wayne; Young, Steven D.; Phillips, Brian T.; Munson, Peter; Whitter, Willie; Liverton, Nigel; Dieckhaus, Christine; Butcher, John; McCauley, John A.; McIntyre, Charles J.; Layton, Mark E.; Sanderson, Philip E.
Patent: US2005/54658 A1, 2005 ;
Location in patent: Page/Page column 49 ;
US 20050054658 A1
反应条件
1: triethylamine / dichloromethane / 20 °C 2: Dess-Martin periodane / dichloromethane / 20 °C View Scheme
反应条件
1: triethylamine / dichloromethane / 20 °C 2: Dess-Martin periodane / dichloromethane / 20 °C View Scheme
反应条件
1: triethylamine; trimethylsilylazide / dichloromethane; acetic acid / 0 - 20 °C 2: palladium 10 on activated carbon; hydrogen / acetic acid / 20 °C / 724.03 Torr / |Inert atmosphere View Scheme
参考文献
Tetrahedron Letters, , vol. 51, # 42 p. 5521 - 5524
反应条件
sodium tetrahydroborate in ethanol T=0°C; 2.5 h;
参考文献
US2005/54658 A1, ;
Page/Page column 49 ;
US 20050054658 A1
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong
Patent: WO2014/74675 A1, 2014 ;
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=0 - 20°C; 18 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; LAWSON, John, David; WALLACE, Michael, B.; KANOUNI, Toufike
Patent: WO2010/144486 A1, 2010 ;
Location in patent: Page/Page column 94-95 ;
WO 2010/144486 A1
