1-[[2-(4-氯苯基)乙基]氨基]-2-羟基丙烷合成路线 （共 5 条）
反应条件
1: With borane-THF in tetrahydrofuran 16 h; Heating / reflux; 2: With sodium hydroxide in water 1 h;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/70111 A2, 2008 ;
Location in patent: Page/Page column 20 ;
WO 2008/070111 A2
反应条件
1: With sodium tetrahydroborate; iodine in tetrahydrofuran T=-10 - 70°C; 4 h; 2: With methanol in tetrahydrofuran T=0 - 65°C; 0.5 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/70111 A2, 2008 ;
Location in patent: Page/Page column 22-23 ;
WO 2008/070111 A2
反应条件
in toluene T=85 - 100°C; 2.25 h;
参考文献
US2009/143576 A1, ;
Page/Page column 2; 10-11 ;
反应条件
1: T=114 - 120°C; 3.16667 h; Reflux; 2: With sodium hydroxide in water T=70 - 73°C; 0.0833333 h; Product distribution / selectivity;
参考文献
WO2010/148207 A2, ;
Page/Page column 35 ;
反应条件
thionyl chloride; N,N-dimethyl acetamide in toluene T=40 - 62°C; 3 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/70111 A2, 2008 ;
Location in patent: Page/Page column 22-23 ;
WO 2008/070111 A2
