Cbz-1-氨基环丙烷羧酸合成路线 （共 8 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water 16 h; Ambient temperature;
参考文献
Chu; Claiborne; Clement; Plattner
Canadian Journal of Chemistry, 1992 , vol. 70, # 5 p. 1328 - 1337
反应条件
sodium hydrogencarbonate in methanol
参考文献
Synlett, , # 14 p. 2489 - 2492
反应条件
sodium hydroxide in methanol T=75°C; 1 h;
参考文献
Strazewski, Peter; Tamm, Christoph
Synthesis, 1987 , # 3 p. 298 - 299
反应条件
sodium hydroxide; sodium; diethyl 2-acetylaminomalonate 1. ethanol, 4 h, reflux; 2. aq. methanol, NaOH, 1 h; Yield given. Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 8 p. 2291 - 2305
反应条件
1: With benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide 15 h; 2: With hydrogen; 5-palladium/activated carbon in ethanol T=200°C; 5.08333 h;
参考文献
US2009/105264 A1, ;
Page/Page column 25 ;
US 20090105264 A1
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-10 - 20°C; 0.5 h; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=0 - 20°C; 2 h; 3: With hydrogenchloride; sodium hydrogencarbonate more than 3 stages;
参考文献
WO2008/64157 A1, ;
Page/Page column 103 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; water
参考文献
Strazewski, Peter; Tamm, Christoph
Synthesis, 1987 , # 3 p. 298 - 299
反应条件
1: EDCl; NH4Cl / dimethylformamide
2: Lawesson's reagent / tetrahydrofuran / 50 °C
View Scheme
参考文献
Kuduk, Scott D.; Ng, Christina; Chang, Ronald K.; Bock, Mark G.
Tetrahedron Letters, 2003 , vol. 44, # 7 p. 1437 - 1440
