5-溴甲基异噁唑-3-甲酸乙酯合成路线 （共 12 条）
反应条件
sodium hydrogencarbonate in water; ethyl acetate
T=20°C; 24 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 148 ;
WO 2010/142801 A1
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=-15°C; 2 h;
参考文献
Mao, Jialin; Yuan, Hai; Wang, Yuehong; Wan, Baojie; Pieroni, Marco; Huang, Qingqing; Van Breemen, Richard B.; Kozikowski, Alan P.; Franzblau, Scott G.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 6966 - 6978
反应条件
1: in diethyl ether; toluene
T=0°C; 0.416667 h;
2: With triethylamine in diethyl ether; toluene
T=0°C; 6.33333 h; Cooling with ice;
参考文献
Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6757 - 6767
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=95°C; 4 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
