3-环戊烯-1,1-二甲酸二甲酯合成路线 （共 20 条）
反应条件
1: malonic acid dimethyl ester With sodium methylate in methanol T=0 - 20°C; 0.666667 h; 2: (cis,trans)-1,4-dichlorobut-2-ene in methanol T=0 - 20°C; 12 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 7 p. 2427 - 2430
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride T=25°C; 14 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 49, # 5 p. 928 - 931
反应条件
sodium methylate in methanol T=22 - 34°C;
参考文献
Journal of Organic Chemistry, , vol. 76, # 1 p. 277 - 280
反应条件
potassium hydroxide; water 1) 16 h, reflux, ethanol; Yield given. Multistep reaction;
参考文献
, vol. No. 11, p. 1999 - 2040
反应条件
lithium chloride in dimethyl sulfoxide T=150°C; 3 h;
参考文献
Wainwright, Phillip; Maddaford, Adrian; Bissell, Richard; Fisher, Ray; Leese, David; Lund, Andrew; Runcie, Karen; Dragovich, Peter S.; Gonzalez, Javier; Kung, Pei-Pei; Middleton, Donald S.; Pryde, David C.; Stephenson, Peter T.; Sutton, Scott C.
Synlett, 2005 , # 5 art. no. D36004ST, p. 765 - 768
反应条件
hydrogenchloride; potassium hydroxide in methanol; water
参考文献
MERRELL DOW PHARMACEUTICALS INC.
Patent: EP339669 A1, 1989 ;
EP 0339669 A1
反应条件
1: 45percent KOH / aq. ethanol / 15 h / Heating 2: 100 percent / 1 h / 185 - 195 °C View Scheme
参考文献
Denonne, Frederic; Celanire, Sylvain; Christophe, Bernard; Defays, Sabine; Delaunoy, Christel; Delporte, Marie-Laure; Detrait, Eric; Durieu, Veronique; Gillard, Michel; Lamberty, Yves; Lorent, Genevieve; Nicolas, Jean-Marie; van Bellinghen, Alain; van Houtvin, Nathalie; Provins, Laurent
ChemMedChem, 2011 , vol. 6, # 9 p. 1559 - 1565
反应条件
1: 78 percent / LiCl / dimethylsulfoxide / 3 h / 150 °C 2: 72 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Synlett, , # 5 art. no. D36004ST, p. 765 - 768
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0 - 20°C; Inert atmosphere;
2: With sodium hydroxide; water in diethyl ether
参考文献
Broggi, Julie; Joubert, Nicolas; Diez-Gonzalez, Silvia; Berteina-Raboin, Sabine; Zevaco, Thomas; Nolan, Steven P.; Agrofoglio, Luigi A.
Tetrahedron, 2009 , vol. 65, # 6 p. 1162 - 1170
反应条件
water; potassium hydroxide in ethanol
1 h; Reflux;
参考文献
Denonne, Frederic; Celanire, Sylvain; Christophe, Bernard; Defays, Sabine; Delaunoy, Christel; Delporte, Marie-Laure; Detrait, Eric; Durieu, Veronique; Gillard, Michel; Lamberty, Yves; Lorent, Genevieve; Nicolas, Jean-Marie; van Bellinghen, Alain; van Houtvin, Nathalie; Provins, Laurent
ChemMedChem, 2011 , vol. 6, # 9 p. 1559 - 1565
