2-氨基-6-甲基-3-吡啶羧酸合成路线 （共 10 条）
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1958 , vol. 80, p. 3449,3454
反应条件
ueber mehrere Stufen;
参考文献
Burroughs Wellcome and Co.
Patent: US2749345 , 1953 ;
反应条件
ammonia in methanol
T=120°C;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/51304 A2, 2005 ;
Location in patent: Page/Page column 145-146 ;
WO 2005/051304 A2
反应条件
potassium hydroxide
T=110°C; 2 h;
参考文献
Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; Schwarcz, Robert; Costantino, Gabriele
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9482 - 9495
反应条件
1: With water; sodium hydroxide
2 h; Reflux;
2: With hydrogenchloride in water
pH=3;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2248423 A1, 2010 ;
Location in patent: Page/Page column 267-268 ;
反应条件
1: ethanolic NH3 / 130 - 150 °C
2: aqueous H3PO4 / 140 °C
View Scheme
参考文献
Lespagnol et al.
Bulletin de la Societe de Pharmacie de Lille, 1955 , p. 60
参考文献
Dornow; v.Loh
Archiv der Pharmazie (Weinheim, Germany), 1957 , vol. 290, p. 136,143
参考文献
Dornow; Neuse
Chemische Berichte, 1951 , vol. 84, p. 296,300
参考文献
Dornow; Karlson
Chemische Berichte, 1940 , vol. 73, p. 542,546
反应条件
1: POCl3; chlorobenzene; PCl5
2: ethanolic NH3 / 130 - 150 °C
3: aqueous H3PO4 / 140 °C
View Scheme
参考文献
Lespagnol et al.
Bulletin de la Societe de Pharmacie de Lille, 1955 , p. 60
