4-溴-1-甲基-1H-吡唑-3-羧酸合成路线 （共 6 条）
反应条件
potassium permanganate in water T=60°C;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
bromine in acetic acid
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
1: 50 percent / KMnO4 / H2O / Ambient temperature; several weeks 2: 27.4 percent / bromine / acetic acid View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
1: With borane-THF in tetrahydrofuran T=60°C; 2: With water; sodium hydrogencarbonate in tetrahydrofuran; ethyl acetate
参考文献
OSI Pharmaceuticals, LLC
Patent: US2011/281888 A1, 2011 ;
Location in patent: Page/Page column 42 ;
反应条件
1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonium chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C 2: N,N-dimethyl-formamide; thionyl chloride / 0 °C View Scheme
反应条件
sulfuric acid; nitric acid
T=65 - 70°C; 2 h;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
