1-(N-甲基)-4-氯-3-吡唑甲酸合成路线 （共 4 条）
反应条件
1: With water; potassium hydroxide in 2-methyl tetrahydrofuran T=40°C; 2: With hydrogenchloride in 2-methyl tetrahydrofuran; water T=20°C; pH=< 7; Cooling; Product distribution / selectivity;
参考文献
WO2009/123714 A2, ;
Page/Page column 54-55 ;
WO 2009/123714 A2
反应条件
potassium permanganate in water T=60°C;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
chlorine in acetic acid
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
1: 50 percent / KMnO4 / H2O / Ambient temperature; several weeks 2: 20 percent / chlorine / acetic acid View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
