5-羟甲基-1-甲基-1H-吡唑合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran cooling;
参考文献
Seto, Masaki; Miyamoto, Naoki; Aikawa, Katsuji; Aramaki, Yoshio; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 363 - 386
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 4 p. 961 - 982
反应条件
lithium aluminium tetrahydride in methanol 0.666667 h; Heating;
参考文献
Perevalov, V. P.; Karim, A. K. Kh.; Andreeva, M. A.; Rumyantsev, E. G.; Stepanov, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
thionyl chloride in dichloromethane
T=20°C; 2 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
