1-甲基-1H-吡唑-3-甲酰氯合成路线 （共 6 条）
反应条件
thionyl chloride 4 h; Heating;
参考文献
Perevalov, V. P.; Karim, A. K. Kh.; Andreeva, M. A.; Rumyantsev, E. G.; Stepanov, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
hydrogen; palladium 10 on activated carbon in toluene 8 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 39-40 ;
WO 2004/058763 A1
反应条件
lithium aluminium tetrahydride in diethyl ether 0.666667 h; Heating;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
1: diethyl ether; ethanol / 20 °C 2: hydrogenchloride / water / |Reflux View Scheme
参考文献
Taydakov, Ilya; Krasnoselskiy, Sergey
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 6 p. 1422 - 1424
反应条件
1: LiAlH4 / diethyl ether / 0.67 h / Heating
2: SOCl2 / 0.25 h / Heating
3: 45 percent / dimethylformamide / 2 h / Heating
4: 40 percent / EtOLi / ethanol / 2 h / Heating
View Scheme
参考文献
Perevalov, V. P.; Karim, A. K. Kh.; Andreeva, M. A.; Rumyantsev, E. G.; Stepanov, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
1: 71 percent / triethylamine / benzene / 2 h / 40 °C / 20 degC, overnight
2: 1. POCl3; 2. 10percent aq. NaOH / 1. dioxane, 80 degC, 4h
View Scheme
参考文献
Prizhiyalgovskaya, N. M.; Kon'kov, L. I.; Tarshits, D. L.; Salmina, S. V.; Segizova, N. T.; Suvorov, N. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 7 p. 751 - 754
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 7 p. 915 - 918
