(2S,4R)-BOC-Γ-甲磺酰基氧甲基脯氨酸甲酯合成路线 （共 30 条）
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
SPINIFEX PHARMACEUTICALS PTY LTD; MCCARTHY, Thomas David; NAYLOR, Alan
Patent: WO2013/102242 A1, 2013 ;
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
SPINIFEX PHARMACEUTICALS PTY LTD; MCCARTHY, Thomas David; NAYLOR, Alan
Patent: WO2013/102242 A1, 2013 ;
反应条件
1: NaN3 2: H2 / Pd/BaSO4 View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 3: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 4: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 5: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
in dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US5821261 A1, 1998 ;
反应条件
cesium fluoride in tert-butyl alcohol T=100°C; 7 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 3: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 4: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
in dimethyl sulfoxide T=90°C;
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 6.74 g / NaN3 / dimethylformamide / 60 °C
2: 2N NaOH / dioxane / 1 h / 25 °C
3: conc. HCl / dioxane / 2 h / 50 °C / pH 2
View Scheme
参考文献
Nagel, Yvonne A.; Kuemin, Michael; Wennemers, Helma
Chimia, 2011 , vol. 65, # 4 p. 264 - 267
