4-[[1-[(4-氟苯基)甲基]-1H-苯并咪唑-2-基]氨基]哌啶-1-甲酸乙酯合成路线 （共 18 条）
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=70 - 80°C; 20 h;
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
T=180°C; 1 h; microwave irradiation;
参考文献
Martin, Rainer E.; Green, Luke G.; Guba, Wolfgang; Kratochwil, Nicole; Christ, Andreas
Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6291 - 6294
反应条件
sodium hydroxide in water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4835161 A1, 1989 ;
反应条件
oxygen; palladium diacetate in 2-methyl tetrahydrofuran T=75°C; 18 h; Molecular sieve;
参考文献
Vlaar, Tjostil; Cioc, Razvan C.; Mampuys, Pieter; Maes, Bert U. W.; Orru, Romano V. A.; Ruijter, Eelco
Angewandte Chemie - International Edition, 2012 , vol. 51, # 52 p. 13058 - 13061
Angew. Chem., 2012 , vol. 124, # 52 p. 13235 - 13238,4
反应条件
1.1: sodium hydroxide / water / 0 °C 1.2: 60 °C 2.1: ethanol 3.1: sulfur; mercury(II) oxide / ethanol / Heating 4.1: sodium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6274 - 6280
反应条件
1: ethanol 2: sulfur; mercury(II) oxide / ethanol / Heating 3: sodium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6274 - 6280
反应条件
1: sulfur; mercury(II) oxide / ethanol / Heating 2: sodium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6274 - 6280
反应条件
1: triethylamine / tetrahydrofuran / 24 h / |Reflux 2: palladium diacetate; oxygen / 2-methyl tetrahydrofuran / 18 h / 75 °C / |Molecular sieve View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 52 p. 13058 - 13061
Angew. Chem., , vol. 124, # 52 p. 13235 - 13238,4
反应条件
1: 72 percent / phosphoryl chloride / 4 h / Heating 2: 1.) NaH / 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5 h 3: 56 percent / 5 h / 125 °C View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 1.) NaH / 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5 h 2: 56 percent / 5 h / 125 °C View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
