2-氨基-3-硝基-6-溴吡啶合成路线 （共 9 条）
反应条件
1: With hydrogen bromide in water; acetic acid T=100°C; 26 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2004/2986 A2, 2004 ;
Location in patent: Page 127-128 ;
WO 2004/002986 A2
反应条件
ammonia in ethanol T=20°C; 19 h;
参考文献
US6348474 B1, ;
Page column 136 ;
反应条件
P2O5; hydrogen bromide; acetic acid in toluene
参考文献
Arienti, Kristen L.; Axe, Frank U.; Breitenbucher, J. Guy; Huang, Liming; Lee, Alice; McClure, Kelly J.
Patent: US2003/176438 A1, 2003 ;
反应条件
1: 61 percent / Pd(OAc)2; Ph3P; Et3N / dimethylformamide / 15 h / 60 °C / 11400 Torr 2: 79 percent / H2 / Pd/C / methanol; ethyl acetate / 4 h View Scheme
参考文献
Renneberg, Dorte; Dervan, Peter B.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5707 - 5716
反应条件
palladium diacetate; triethylamine; triphenylphosphine in N,N-dimethyl-formamide T=60°C; P=11400 Torr; 15 h;
参考文献
Renneberg, Dorte; Dervan, Peter B.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5707 - 5716
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; ethanol; water T=100°C; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
van Duzer, John H.; Mazitschek, Ralph
Patent: US2014/128391 A1, 2014 ;
Location in patent: Paragraph 0217; 0218; 0219 ;
反应条件
hydrogenchloride; iron in ethanol; water T=20°C; 2 h; Heating / reflux;
参考文献
Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin
Patent: US2010/222345 A1, 2010 ;
Location in patent: Page/Page column 91 ;
反应条件
hydrogenchloride in ethanol (220 ml)-water; water
参考文献
Fujisawa Pharmaceutical Co. Ltd.
Patent: US6573274 B1, 2003 ;
