2-[4-[(甲磺酰)氧]苯基]-苯并[b]噻吩-6-醇 6-甲烷磺酸合成路线 （共 8 条）
反应条件
1: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 2: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme
参考文献
Sach, Neal W.; Richter, Daniel T.; Cripps, Stephan; Tran-Dube, Michelle; Zhu, Huichun; Huang, Buwen; Cui, Jean; Sutton, Scott C.
Organic Letters, 2012 , vol. 14, # 15 p. 3886 - 3889
反应条件
trifluorormethanesulfonic acid in dichloromethane
参考文献
Eli Lilly and Company
Patent: US4418068 A1, 1983 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C
2: 71 percent / pyridine hydrochloride / 6 h / 220 °C
3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 92 percent / AlCl3 / 1,2-dichloro-ethane / 16 h
2: 79 percent / 5 N aq. NaOH / tetrahydrofuran; methanol / 60 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
