4-三氟甲基-联苯-2-甲酸合成路线 （共 24 条）
反应条件
1: With potassium hydroxide in 1-methyl-pyrrolidin-2-one T=20 - 95°C; Reflux; 2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water T=10 - 20°C; pH=1 - 2; 3 h;
参考文献
SALTIGO GMBH
Patent: US2012/16152 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: With palladium diacetate in water T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; 2: With potassium hydroxide in water T=20 - 75°C; 5 h;
参考文献
Korolev, Dmitrii N.; Bumagin, Nikolay A.
Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4225 - 4229
参考文献
Eaddy, III; John F.
Patent: US4578522 A1, 1986 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in acetonitrile T=90°C; Suzuki coupling reaction; 12 h;
参考文献
Tao, Bin; Goel, Subhash C.; Singh, Jagvir; Boykin, David W.
Synthesis, 2002 , # 8 p. 1043 - 1046
反应条件
potassium permanganate in water; acetone T=50°C; 2 h;
参考文献
Dupuis, Christophe; Adiey, Kouacou; Charruault, Lise; Michelet, Veronique; Savignac, Monique; Genet, Jean-Pierre
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6523 - 6526
反应条件
potassium permanganate in sodium hydroxide; water; tert-butyl alcohol
反应条件
in water; toluene; tert-butyl alcohol
反应条件
1: 76 percent / aq. NaOH; KMnO4 / 3 h / 50 °C 2: 72 percent / aq. K2CO3 / Pd(PPh3)4 / acetonitrile / 12 h / 90 °C View Scheme
参考文献
Synthesis, , # 8 p. 1043 - 1046
反应条件
1: PdCl2(dppf); K3PO4 / 1,2-dimethoxy-ethane / 16 h / Heating 2: 1 N aq. NaOH / ethanol / 5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 26 p. 4677 - 4687
