1-Boc-4-哌啶甲酸合成路线 （共 100 条）
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 2: With hydrogenchloride in water
参考文献
Su, Weiguo; Zhang, Weihan; Yang, Haibin
Patent: US2013/190307 A1, 2013 ;
Location in patent: Paragraph 0205; 0206 ;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2006/21449 A1, 2006 ;
Location in patent: Page/Page column 8; 9 ;
参考文献
Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH
Patent: US2005/261341 A1, 2005 ;
反应条件
sodium hydroxide in water
参考文献
MITSUBISHI CHEMICAL CORPORATION
Patent: EP881220 A1, 1998 ;
反应条件
triethylamine in dichloromethane
参考文献
Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Ridgill, Mark Peter; Shaw, Duncan Edward
Patent: US2001/39286 A1, 2001 ;
反应条件
4-(N,N-dimethlyamino)pyridine; sodium hydroxide; 1,2-dichloro-ethane; benzyl alcohol in tetrahydrofuran; dichloromethane; water; ethyl acetate
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 72 h;
参考文献
EP1426366 A1, ;
Page 45-46 ;
反应条件
1: Et3N 2: aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
反应条件
sodium hydroxide in diethyl ether; water; ethyl acetate; tert-butyl alcohol
参考文献
US5998439 A1, ;
US 5998439 A
