苄基(2S)-2-苄氧羰基氨基-6-羟基己酸酯合成路线 （共 15 条）
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
caesium carbonate in N,N-dimethyl-formamide T=0 - 20°C; 12 h;
参考文献
WO2004/72047 A1, ;
Page 80; 81 ;
WO 2004/072047 A1
反应条件
triethylamine in acetone
参考文献
Schmitt, Martin L.; Hauser, Alexander-Thomas; Carlino, Luca; Pippel, Martin; Schulz-Fincke, Johannes; Metzger, Eric; Willmann, Dominica; Yiu, Teresa; Barton, Michelle; Schuele, Roland; Sippl, Wolfgang; Jung, Manfred
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7334 - 7342
反应条件
1: 77 percent / Na2<Fe(III)(CN)5NO>*2H2O, 4M NaOH / H2O / 6.5 h / 60 °C / pH 9.5 2: NEt3, sodium sulphate / acetone / 18 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 9 p. 2633 - 2636
反应条件
1.1: zinc; TMSCl; 1,2-dibromoethane / dimethylformamide / 0.33 h / 60 °C 1.2: 100 percent / CuCN; LiCl / dimethylformamide / -55 - 0 °C 2.1: BH3*SMe2 / tetrahydrofuran / 0 - 20 °C 2.2: 68.3 percent / H2O2; NaOAc / H2O; tetrahydrofuran / 12 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 41 p. 9628 - 9634
反应条件
1: 1.) 1M NaOH, 2.) hydrochloric acid / 1.) ethanol, - 20 deg C, 2.) ethanol, water, 50 deg C, 5 min 2: 77 percent / Na2<Fe(III)(CN)5NO>*2H2O, 4M NaOH / H2O / 6.5 h / 60 °C / pH 9.5 3: NEt3, sodium sulphate / acetone / 18 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 9 p. 2633 - 2636
反应条件
1: 80 percent / 2M LiOH / 2 h / 4 °C 2: 1.) 1M NaOH, 2.) hydrochloric acid / 1.) ethanol, - 20 deg C, 2.) ethanol, water, 50 deg C, 5 min 3: 77 percent / Na2<Fe(III)(CN)5NO>*2H2O, 4M NaOH / H2O / 6.5 h / 60 °C / pH 9.5 4: NEt3, sodium sulphate / acetone / 18 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 9 p. 2633 - 2636
反应条件
1: 22 percent / Ambient temperature 2: 99 percent Turnov. / NaBH4 / methanol / 0.03 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 15 p. 818 - 819
反应条件
sodium tetrahydroborate in methanol 0.0333333 h; Heating;
参考文献
Baldwin, Jack E.; Harrison, Paul; Murphy, John A.
Journal of the Chemical Society, Chemical Communications, 1982 , # 15 p. 818 - 819
反应条件
1: lithium hydroxide hydrate / 4 °C 2: sodium hydroxide / ethanol / -20 °C 3: sodium hydroxide; sodium nitroferricyanide (III) / pH 9.5 4: triethylamine View Scheme
参考文献
Bioconjugate Chemistry, , vol. 24, # 1 p. 26 - 35
