反-3-(4-吡啶基)烯丙酸合成路线 （共 16 条）
反应条件
malonic acid in pyridine
参考文献
ELI LILLY AND COMPANY
Patent: EP846687 A1, 1998 ;
Title/Abstract Full Text Show Details
Eli Lilly and Company
Patent: US5972972 A1, 1999 ;
US 5972972 A
反应条件
pyridine; malonic acid in ethanol
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 24 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
Tetsuhashi, Masashi; Ishikawa, Minoru; Hashimoto, Mariko; Hashimoto, Yuichi; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5323 - 5338
反应条件
ammonium acetate in butan-1-ol Heating;
参考文献
Lebedev; Lebedeva; Sheludyakov; Kovaleva; Ustinova; Kozhevnikov
Russian Journal of General Chemistry, 2005 , vol. 75, # 7 p. 1113 - 1124
反应条件
1: palladium diacetate; triphenylphosphine; potassium carbonate / N,N-dimethyl-formamide / 20 h / 130 °C / |Inert atmosphere 2: potassium hydroxide / ethanol; water / 20 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 3 p. 770 - 792
参考文献
Chemische Berichte, , vol. 91, p. 1621,1629
反应条件
1: ethanolic HCl 2: Raney nickel; anhydrous ethanol / 150 °C / 132391 Torr / Hydrogenation View Scheme
参考文献
Clemo; Popli
Journal of the Chemical Society, 1951 , p. 1406,1408
反应条件
hydrogen; palladium 10 on activated carbon in methanol; dichloromethane T=23°C; P=760.051 Torr; 24 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58702 A2, 2004 ;
Location in patent: Page 46; 27 ;
WO 2004/058702 A2
反应条件
1: 100 percent / ammonia; H2 / Ru on alumina / H2O / 72 h / 45003.6 Torr 2: 81 percent / NaHCO3; DMAP / tetrahydrofuran; H2O / 120 h View Scheme
参考文献
Merck and Co., Inc.
Patent: US6399619 B1, 2002 ;
US 6399619 B1
反应条件
triethylamine; Pd-C in n-heptane; water; acetic acid; toluene
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6538007 B1, 2003 ;
