2-氨基-5-氯-3-硝基苯甲酸甲酯合成路线 （共 7 条）
反应条件
in methanol; diethyl ether
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 96-97 ;
WO 2010/115736 A2
反应条件
1: 67 percent / dioxane / 12 h / 20 °C
2: 82 percent / conc. H2SO4; KNO3 / 24 h / 20 °C
3: 82 percent / NaOH / H2O / 3 h / Heating
4: SOCl2 / 3 h / Heating
5: 172 mg / 12 h / 20 °C
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 82 percent / conc. H2SO4; KNO3 / 24 h / 20 °C
2: 82 percent / NaOH / H2O / 3 h / Heating
3: SOCl2 / 3 h / Heating
4: 172 mg / 12 h / 20 °C
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 82 percent / NaOH / H2O / 3 h / Heating
2: SOCl2 / 3 h / Heating
3: 172 mg / 12 h / 20 °C
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: SOCl2 / 3 h / Heating
2: 172 mg / 12 h / 20 °C
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: With water; lithium hydroxide hydrate
1 h; Reflux;
2: With hydrogenchloride in water
T=20°C; pH=2;
参考文献
Bayer CropScience AG; The designation of the inventor has not yet been filed
Patent: EP2561759 A1, 2013 ;
Location in patent: Paragraph 0062-0063 ;
