N-[(1-乙基-2-吡咯烷基)甲基]-2-羟基-3-碘-6-甲氧基-苯甲酰胺合成路线 （共 6 条）
反应条件
hydrogenchloride; boron tribromide in dichloromethane T=20°C; 0.5 h;
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: 70 percent / ICl / acetic acid / 1.) reflux, 3 h, 2.) room temperature, 18 h 2: SOCl2, DMF / CHCl3 / 2 h / Heating 3: CHCl3 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043
反应条件
1: 60 percent / HBr, AcOH / CHCl3 / 20 h / Ambient temperature 2: 70 percent / ICl / acetic acid / 1.) reflux, 3 h, 2.) room temperature, 18 h 3: SOCl2, DMF / CHCl3 / 2 h / Heating 4: CHCl3 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043
反应条件
1: SOCl2, DMF / CHCl3 / 2 h / Heating 2: CHCl3 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043
反应条件
1: SOCl2, DMF / toluene / 1 h / 65 °C 2: 55 percent / CHCl3 / 0.5 h / 25 °C 3: 73 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 9 p. 1263 - 1269
反应条件
in chloroform 2 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 1039 - 1043
