4-羟基-2-甲氧基苯甲腈合成路线 （共 7 条）
反应条件
pyridine; trifluoroacetic anhydride in tetrahydrofuran
T=20°C; 18 h;
参考文献
Bradley, Paul Anthony; Dack, Kevin Neil; Marsh, Ian Roger
Patent: US2006/241125 A1, 2006 ;
Location in patent: Page/Page column 20 ;
反应条件
1,3-dimethyl-imidazolidin-2-one; lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=185°C; 12 h; further reagent: NaN(SiMe3)2;
参考文献
Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4097 - 4104
反应条件
2-(N,N-diethylamino)ethanethiol hydrochloride; sodium t-butanolate in N,N-dimethyl-formamide
0.25 h; Heating;
参考文献
Magano, Javier; Chen, Michael H.; Clark, Jerry D.; Nussbaumer, Thomas
Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7103 - 7105
反应条件
quinoline; copper
T=240°C;
参考文献
Spaeth; Klager
Chemische Berichte, 1934 , vol. 67, p. 859,864
反应条件
lithium cyanide in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Kurihara, Takushi; Harusawa, Shinya; Hirai, Jun-ichi; Yoneda, Ryuji
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1771 - 1776
反应条件
2: 140 °C / und Erwaermen des Reaktionsprodukts mit wss.NaOH auf 55grad
View Scheme
参考文献
Spaeth; Klager
Chemische Berichte, 1934 , vol. 67, p. 859,864
反应条件
T=145°C; Erwaermen des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Spaeth; Klager
Chemische Berichte, 1934 , vol. 67, p. 859,864
