5-溴-2-氯-n3-乙基吡啶-3,4-二胺合成路线 （共 8 条）
反应条件
hydrogenchloride; SnCl2·2H2O in water
T=20°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/11700 A1, 2005 ;
Location in patent: Page/Page column 122 ;
WO 2005/011700 A1
反应条件
hydrogenchloride; tin(ll) chloride in water
T=85°C; 1 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/58850 A2, 2007 ;
Location in patent: Page/Page column 38 ;
WO 2007/058850 A2
反应条件
in hydrogenchloride; water
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: water; tetrahydrofuran
2: hydrogenchloride; water
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/11700 A1, 2005 ;
Location in patent: Page/Page column 87 ;
WO 2005/011700 A1
反应条件
1: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
2: acetic acid
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
2: acetic acid
3: sodium nitrite
4: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
2: acetic acid
3: sodium nitrite
4: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
5: hydrogenchloride; sodium hydroxide; dihydrogen peroxide / ethyl acetate; toluene; water; isopropylmagnesium chloride; tetrahydrofuran
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
