2-乙酰-5-溴-6-甲氧基萘合成路线 （共 6 条）
反应条件
Oxonereg;; NH4Br in methanol T=20°C; 0.666667 h; regioselective reaction;
参考文献
MacHarla, Arun Kumar; Chozhiyath Nappunni, Rohitha; Marri, Mahender Reddy; Peraka, Swamy; Nama, Narender
Tetrahedron Letters, 2012 , vol. 53, # 2 p. 191 - 195
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide; trimethylhexadecylammonium chloride in 1,2-dichloro-ethane T=70°C; Friedel-Crafts Acylation; 0.0833333 h; Microwave irradiationMicellar solution;
参考文献
Rajendar Reddy; Rajanna; Uppalaiah
Tetrahedron Letters, 2013 , vol. 54, # 26 p. 3431 - 3436
反应条件
2-carboxyethyl triphenyl phosphonium tribromide in tetrahydrofuran T=25°C; 24 h; Further byproducts given;
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 25, p. 357 - 368
反应条件
hydrogenchloride; sodium hydroxide; aluminium trichloride in water; toluene
参考文献
Alfa Chemicals Italiana S.r.l.
Patent: EP440930 A2, 1991 ;
反应条件
aluminium trichloride
参考文献
Alfa Wassermann S.p.A.
Patent: US5107013 A1, 1992 ;
反应条件
1: 82 percent / p-toluenesulphonic acid / toluene / 4 h / Heating 2: 85.5 percent / 1.6 M n.butyllithium / diethyl ether / 1.) 20 deg C, 45 min; 2.) 1 h, 20 deg C 3: 98 percent / cc. HCl / dioxane / 0.5 h / 60 °C 4: 98 percent / AlCl3 / CH2Cl2 / 24 h / 20 °C 5: 93 percent / KF / methanol / 1.) 15 h, RT; 2.) 4 h, reflux View Scheme
参考文献
Royer; Einhorn; Demerseman; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 429 - 432
