(E)-1-乙酰基-alpha-(5-氟-2-羟基苯基)-N-羟基-4-哌啶甲亚胺合成路线 (共 4 条)
反应条件
1: 1.5 h / 60 °C 2: NaH / dimethylformamide / 16 h / Ambient temperature 3: 6 N aq. HCl / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769
反应条件
ammonium acetate; hydroxylamine hydrochloride in cyclohexane; ethyl acetate
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
反应条件
1: 1.5 h / 60 °C
2: NaH / dimethylformamide / 16 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769