1-乙酰基-4-(5-氟-2-羟基苯甲酰基)哌啶合成路线 （共 4 条）
反应条件
thionyl chloride; aluminium trichloride in anhydrous dichloroethane
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 40 - 65 °C
2: AlCl3 / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
aluminium trichloride in 1,2-dichloro-ethane
4 h; Heating; Yield given;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
ammonium acetate; hydroxylamine hydrochloride in cyclohexane; ethyl acetate
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
