4-(2,4-二氟苯甲酰)-1-哌啶甲醛合成路线 （共 5 条）
反应条件
1: With potassium hydroxide; hydroxylammonium sulfate in methanol 8 h; Heating; 2: With water in methanol 2 h; Heating;
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
1: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 2: potassium hydroxide / isopropyl alcohol; water 3: hydrogenchloride View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
aluminium trichloride in dichloromethane
Friedel-Crafts acylation; 4 h; cooling;
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
反应条件
1.1: acetic anhydride / 1 h / 55 - 60 °C
1.2: 95 percent / 14 h / 0 - 5 °C
2.1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C
3.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling
View Scheme
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
反应条件
1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C
2: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling
View Scheme
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
