(R)-4-(甲基亚磺酰)-1-丁胺合成路线 （共 4 条）
反应条件
sodium hydroxide in chloroform; water 1 h;
参考文献
PharmAgra Labs, Inc.
Patent: US2008/176942 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With triethylamine in ethanol T=20°C; 0.5 h; Inert atmosphere; 2: With 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in ethanol T=0 - 20°C; 2.25 h;
参考文献
Auriga International; Dubois, Jacques; Marchal, Alfred; Lacroix, Damien; Cabou, Jérôme
Patent: US2013/142739 A1, 2013 ;
Location in patent: Paragraph 0129-0147 ;
参考文献
Schmid; Karrer
Helvetica Chimica Acta, 1948 , vol. 31, p. 1497,1500
反应条件
1.1: triethylamine / ethanol / 0.5 h / 20 °C / |Inert atmosphere
1.2: 2.25 h / 0 - 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / -20 - 20 °C / |Inert atmosphere
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参考文献
Auriga International; Dubois, Jacques; Marchal, Alfred; Lacroix, Damien; Cabou, Jérôme
Patent: US2013/142739 A1, 2013 ;
