甲基4-羟基-1-甲基-2-氧代-1,2-二氢喹啉-3-羧酸酯合成路线 （共 12 条）
反应条件
in toluene T=100°C; 4 h;
参考文献
Detsi, Anastasia; Bouloumbasi, Dionysia; Prousis, Kyriakos C.; Koufaki, Maria; Athanasellis, Giorgos; Melagraki, Georgia; Afantitis, Antreas; Igglessi-Markopoulou, Olga; Kontogiorgis, Christos; Hadjipavlou-Litina, Dimitra J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2450 - 2458
反应条件
1: malonic acid dimethyl ester With sodium methylate in N,N-dimethyl-formamide
T=80 - 90°C; 1.5 h; Large scale;
2: 1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione in N,N-dimethyl-formamide
T=83°C; 0.166667 h; Large scale;
参考文献
Sjoevall, Sven; Hansen, Lars; Granquist, Bo
Organic Process Research and Development, 2004 , vol. 8, # 5 p. 802 - 807
反应条件
benzoic acid in ethyl acetate
2 h; Heating;
参考文献
Kamel, Azza A.; Abdou, Wafaa M.
Synlett, 2007 , # 8 p. 1269 - 1273
反应条件
1: iPr2NEt / N,N-dimethyl-acetamide / 3 h / 40 °C
2: 942 mg / NaO-t-Bu / N,N-dimethyl-acetamide / 1 h / 95 °C
View Scheme
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 7058 - 7061
反应条件
1: NaBH(OAc)3 / CH2Cl2 / 18 h / Ambient temperature
2: Na2CO3, H2O / CH2Cl2 / 0.5 h / Ambient temperature
3: 1.) Amberlyst A-26 (OH(-) form), 2.) TFA / 1.) MeOH, r.t., 16 h, 2.) MeOH, r.t., 30 min
View Scheme
参考文献
Kulkarni, Bheemashankar A.; Ganesan
Chemical Communications, 1998 , # 7 p. 785 - 786
反应条件
1: Na2CO3, H2O / CH2Cl2 / 0.5 h / Ambient temperature
2: 1.) Amberlyst A-26 (OH(-) form), 2.) TFA / 1.) MeOH, r.t., 16 h, 2.) MeOH, r.t., 30 min
View Scheme
参考文献
Kulkarni, Bheemashankar A.; Ganesan
Chemical Communications, 1998 , # 7 p. 785 - 786
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Zikou, Lamprini; Athanasellis, Giorgos; Detsi, Anastasia; Zografos, Alexandros; Mitsos, Christos; Igglessi-Markopoulou, Olga
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 8 p. 1505 - 1508
反应条件
1: (N-methylamino)benzoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran
2: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran
Further stages.;
参考文献
Detsi, Anastasia; Bouloumbasi, Dionysia; Prousis, Kyriakos C.; Koufaki, Maria; Athanasellis, Giorgos; Melagraki, Georgia; Afantitis, Antreas; Igglessi-Markopoulou, Olga; Kontogiorgis, Christos; Hadjipavlou-Litina, Dimitra J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2450 - 2458
反应条件
1: N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 3 - 5 °C
2: 1.5 g / NaH / tetrahydrofuran / 2.5 h / 20 °C
View Scheme
参考文献
Zikou, Lamprini; Athanasellis, Giorgos; Detsi, Anastasia; Zografos, Alexandros; Mitsos, Christos; Igglessi-Markopoulou, Olga
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 8 p. 1505 - 1508
反应条件
in 1,4-dioxane
72 h; Heating;
参考文献
Kamel, Azza A.; Abdou, Wafaa M.
Synlett, 2007 , # 8 p. 1269 - 1273
